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The A/D bits exist entirely for the operating system's benefit. The Accessed bit tells the OS which pages have been recently used, enabling page replacement algorithms to choose pages to evict when memory runs low. The Dirty bit tells the OS which pages have been modified and must be written back to disk before eviction; clean pages can simply be discarded and re-read from disk later.
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当然，风险亦不容忽视。Infigratinib是泛FGFR1-4抑制剂，对FGFR1等的抑制可能引起高磷血症等副作用。3期试验中约有4%患者出现轻度、短暂的高磷血症。在儿科长期用药的背景下，其安全性仍需更严格的监测，监管的要求也会更严格。